HLA-DP3-restricted peptides from EBNA1 recognized by CD4+ T cells.

2003 FEB 17 - (NewsRx.com & NewsRx.net) -- "The EBV-encoded nuclear antigen 1 (EBNA1) is required for the maintenance and replication of the viral episome in EBV-transformed human B-lymphoblastoid cell lines. It is expressed in all EBV-associate tumors, making it a potentially important target for immunotherapy. However, this promise has not been realized, because an endogenously processed MHC class I-restricted T-cell epitope remains to be identified, and relatively little is known about MHC class II-restricted helper epitopes in the molecule," researchers in the United States report.

"In this report, we identify a T-cell peptide derived from EBNA1 that is …